Regulatory Changes Affecting Refrigeration in the Life Sciences: The Environmental Protection Agency’s AIM Act

The life sciences industry depends on refrigerated systems to store and transport products. These systems must be able to maintain a stable environment and stay within predetermined temperature specifications. The refrigerants used to accomplish this are regulated by the EPA. In 2025, the American Innovation and Manufacturing (AIM) Act took effect, initiating a phase-down in the use of certain hydrofluorocarbons (HFCs) as refrigerants. This white paper examines the implications of these regulatory changes, the challenges they pose to life sciences storage, and provides practical solutions to help you stay compliant and operate more efficiently moving forward.